Assay Validation

  • Lachno DR, Evert BA, Vanderstichele H, Robertson M, DeMattos RB, Konrad RJ, Talbot JA, Racke MM, Dean RA. Validation of assays for measurement of Amyloid-β peptides in cerebrospinal fluid and plasma specimens from patients with Alzheimer’s disease treated with Solanezumab. J Alzheimers Dis 2013; 34: 897-910.

  • Lachno DR, Emerson JK, Vanderstichele H, Gonzales C, Martényi F, Konrad RJ, Talbot JA, Lowe SL, Oefinger PE, Dean RA. Validation of a multiplex assay for simultaneous quantification of Amyloid-β peptide species in human plasma with utility for measurements in studies of Alzheimer’s disease therapeutics. J Alzheimer’s Dis 2012; 32: 905 – 918.

  • Lachno DR, Romeo MJ, Siemers ER, Vanderstichele H, Coart E, Konrad RJ, Zajac JJ, Talbot JA, Jensen HF, Sethuraman G, Demattos RB, May PC, Dean RA. Validation of ELISA Methods for quantification of total Tau and phosporylated-Tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer’s disease studies. J Alzheimers Dis 2011; 26: 531-541.
Analytical standardization ⇑